Directorate Change.

05 August 2025

Syncona Limited

("Syncona" or the "Company")

Directorate Change

As previously announced, following Syncona Limited's Annual General Meeting ("AGM"), Virginia Holmes has retired from the Syncona Board. Kemal Malik will take up the role of Senior Independent Director, effective immediately. He joined the Syncona Board in 2020, bringing 30 years of experience in global pharmaceutical research and development.

In line with the Company's strategy update on 19 June, in the event a new investment objective and policy, is approved by shareholders, the Company would expect to reduce the size of the Board for the new strategy.

Melanie Gee, Chair of Syncona Limited, said: "The Board and Syncona Investment Management Limited team would like to thank Virginia for her invaluable contribution to the Company and dedicated work on behalf of our shareholders. I am delighted that, having worked closely alongside Kemal over the last five years, he is taking up the role of Senior Independent Director, bringing his wealth of expertise to bear, as the SIML team seek to maximise value across the portfolio."

Enquiries

Syncona Ltd

Annabel Clark

Tel: +44 (0) 20 3981 7940

FTI Consulting

Ben Atwell / Tim Stamper

Tel: +44 (0) 20 3727 1000

Forward-looking statements - this announcement contains certain forward-looking statements with respect to the portfolio of investments of Syncona Limited. These statements and forecasts involve risk and uncertainty because they relate to events and depend upon circumstances that may or may not occur in the future. There are a number of factors that could cause actual results or developments to differ materially from those expressed or implied by these forward-looking statements. In particular, many companies in the Syncona Limited portfolio are conducting scientific research and clinical trials where the outcome is inherently uncertain and there is significant risk of negative results or adverse events arising. In addition, many companies in the Syncona Limited portfolio have yet to commercialise a product and their ability to do so may be affected by operational, commercial and other risks.

Syncona Limited seeks to achieve returns over the long term. Investors should seek to ensure they understand the risks and opportunities of an investment in Syncona Limited, including the information in our published documentation, before investing.